Assignment: Off-Label Drug Use in Pediatrics
The unapproved use of approved drugs, also called off-label use, with children is quite common. This is because pediatric dosage guidelines are typically unavailable, since very few drugs have been specifically researched and tested with children.
When treating children, prescribers often adjust dosages approved for adults to accommodate a childâ€™s weight. However, children are not just â€œsmallerâ€ adults. Adults and children process and respond to drugs differently in their absorption, distribution, metabolism, and excretion.
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Children even respond differently during stages from infancy to adolescence. This poses potential safety concerns when prescribing drugs to pediatric patients. As an advanced practice nurse, you have to be aware of safety implications of the off-label use of drugs with this patient group.
By Day 5 of Week 11
Write a 1-page narrative in APA format that addresses the following:
Reminder: The College of Nursing requires that all papers submitted include a title page, introduction, summary, and references. The Sample Paper provided at the Walden Writing Center offers an example of those required elements (available at http://writingcenter.waldenu.edu/57.htm). All papers submitted must use this formatting.
Pleasethis is the interactive
The client is an 8-year-old African American male who arrives at the ER with his mother. He is exhibiting signs of depression.
Â· Client complained of feeling â€œsadâ€
Â· Mother reports that teacher said child is withdrawn from peers in class
Â· Mother notes decreased appetite and occasional periods of irritation
Â· Client reached all developmental landmarks at appropriate ages
Â· Physical exam unremarkable
Â· Laboratory studies WNL
Â· Child referred to psychiatry for evaluation
MENTAL STATUS EXAM
Alert & oriented X 3, speech clear, coherent, goal directed, spontaneous. Self-reported mood is â€œsadâ€. Affect somewhat blunted, but child smiled appropriately at various points throughout the clinical interview. He denies visual or auditory hallucinations. No delusional or paranoid thought processes noted. Judgment and insight appear to be age-appropriate. He is not endorsing active suicidal ideation, but does admit that he often thinks about himself being dead and what it would be like to be dead.
You administer the Children’s Depression Rating Scale, obtaining a score of 30 (indicating significant depression)
Â§ Poznanski, E., & Mokros, H. (1996). Child Depression Rating Scale–Revised. Los Angeles, CA: Western Psychological Services.
please follow this decision steps as indicated
Decision Point One
Begin Paxil 10 mg orally daily
RESULTS OF DECISION POINT ONE
Decision Point Two
Change to Prozac 10 mg orally daily
RESULTS OF DECISION POINT TWO
Decision Point Three
Continue current dose
Guidance to StudentYou have two equally compelling choices at this point. The client has only been taking the current drug at its current dose for 4 weeks. It would be appropriate to continue at current dose. Additionally, you could also increase the dose to 20 mg orally daily. A discussion of risk/benefits should be had with the childs guardian regarding this and collaborative decision making should occur. There is no indication at this point that augmentation agents are required as the child is showing a partial response to therapy.
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